Chemical analysis and cytotoxic evaluation of asphodelus aestivus brot. flowers

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Farid M.M.; Salem M.A.; Abd El-Latif R.R.; Elkhateeb A.; Abdel-Hameed E.-S.S.; Marzouk M.M.; Hussein S.R.

Journal: Egyptian Journal of Chemistry

Publisher: NIDOC (Nat.Inform.Document.Centre)

Publication Date: 4 May 2021

Volume / Issue: Volume 64 / Issue 9

Pages: 5173–5180

ISSN: 4492285

DOI: 10.21608/ejchem.2021.70226.3546

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Bronze Open Access

Authors and Affiliations

Farid M.M., Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, P. O. 12622, Giza, Egypt; Salem M.A., Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, P. O. 12622, Giza, Egypt; Abd El-Latif R.R., Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, P. O. 12622, Giza, Egypt; Elkhateeb A., Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, P. O. 12622, Giza, Egypt; Abdel-Hameed E.-S.S., Laboratory of Medicinal Chemistry, Theodor Bilharz Research Institute, Giza, Egypt; Marzouk M.M., Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, P. O. 12622, Giza, Egypt; Hussein S.R., Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, P. O. 12622, Giza, Egypt

Abstract

Asphodelus species are among many plants used in traditional medicine, they are used by native peoples for various pathologies. Asphodelus aestivus Brot. is one of Asphodelus species which is considered an important wild medicinal plant growing mainly at Mediterranean region. The present study aims to investigate the chemical constituents and cytotoxic evaluation of A. aestivus flowers. Petroleum ether extract was analyzed by GC/MS assay which revealed the characterization of twenty nine compounds, representing 93.13% of total extract. Also, the chromatographic investigation of the hydromethanolic extract led to the isolation of ten phenolics. They were identified as kaempferol (1), kaempferol 3-O-glucoside (2), kaempferol 3,7-di-O-glucoside (3), luteolin 7-O-glucoside )4), isoorientin (5), isoorientin 7-O-glucoside (lutonarin) (6), caffeic acid (7) emodin (8), apigenin 7-O-glucoside (9) and isovitexin-7-O-glucoside (saponarin) (10), from which, five compounds ((2, 3, 6-8) have been isolated for the first time from A. aestivus. Furthermore, LC-ESI-MS chemical profiling managed to detect the minor contents and led to the annotation of thirteen additional metabolites. In addition, the petroleum ether and the hydromethanolic extracts were investigated against four human carcinoma cell lines; HepG2, HCT-116, MCF-7 and A549 at concentration of 100 mg/mL. The results showed moderate % of inhibition against MCF-7 (63.8 and 68.4) followed by HepG2 (52.3 and 65.7), respectively. Both extracts showed weak inhibition (5.7-14.3%) on HCT-116 and A549. To the best of our knowledge, this is considered the first report of the chemical analysis and biological evaluation of A. aestivus flowers. © 2021 National Information and Documentation Center (NIDOC).

Keywords

A. aestivus; Biological activity; GC-MS analysis; LC-ESI-MS

Citation Information

Scopus Citations: 5

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