IL-4, IL-17 and CD163 Immunoexpression and IL-6 Gene Polymorphism in Chronic Hepatitis C Patients and Associated Hepatocellular Carcinoma

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Aboushousha T.; Emad M.; Rizk G.; Ragab K.; Hammam O.; Fouad R.; Helal N.S.

Journal: Asian Pacific Journal of Cancer Prevention

Publisher: Asian Pacific Organization for Cancer Prevention

Publication Date: 1 April 2021

Volume / Issue: Volume 22 / Issue 4

Pages: 1105–1113

ISSN: 15137368

DOI: 10.31557/APJCP.2021.22.4.1105

Scopus: View on Scopus

PubMed: 33906302

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Aboushousha T., Department oF Pathology, Theodor Bilharz Research Institute, Giza, Egypt; Emad M., Faculty of Biotechnology, October University for Modern Sciences and Arts, Giza, Egypt; Rizk G., Faculty of Biotechnology, October University for Modern Sciences and Arts, Giza, Egypt; Ragab K., Department of Hepatology and Gastroenterology, Theodor Bilharz Research Institute, Giza, Egypt; Hammam O., Department oF Pathology, Theodor Bilharz Research Institute, Giza, Egypt; Fouad R., Department of Hematology, Theodor Bilharz Research Institute, Giza, Egypt; Helal N.S., Department oF Pathology, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

Objective: To assess the expression of IL-4, IL-17 and CD-163 as well as study of IL6-572 C/G gene polymorphism in chronic HCV and HCC on top of HCV. Methods: Sixty HCC specimens and 60 adjacent hepatic tissue with HCV of different grades of necro-inflammation and different stages of fibrosis. In addition to 55 HCV, 60 HCC and 50 healthy venous blood samples for evaluation of IL6-572 C/G gene polymorphism. Results: high expression of IL-4, IL-17 and CD163 in higher grades of activity, late stages of fibrosis and higher degrees of steatosis of HCV. IL-4 and CD163 showed higher expression in advanced grades of HCC, while IL-17 more expressed in lower grades. No significant difference in IL6-572 C/G gene polymorphism among studied groups regarding G/C, G/G, C/C frequencies or G and C allele’s frequencies. Conclusion: IL-4, IL-17 and CD163 were associated with HCV severity. Their expression in HCC suggests their important role in HCC development. Blocking of these proteins may be a good target to control inflammation in HCV and can hinder progression to cirrhosis then to HCC. On the other hand, IL6-572 promoter gene polymorphism is neither associated with HCV infection nor with HCC development and its progression. © 2021. All Rights Reserved.

Keywords

CD136; HCC; HCV; IL-17; IL-4; IL-6; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers, Tumor; Carcinoma, Hepatocellular; Genetic Predisposition to Disease; Genotype; Hepatitis C, Chronic; Humans; Interleukin-17; Interleukin-4; Interleukin-6; Liver Neoplasms; Receptors, Cell Surface; CD163 antigen; cell surface receptor; differentiation antigen; interleukin 17; interleukin 4; interleukin 6; leukocyte antigen; tumor marker; chronic hepatitis C; genetic predisposition; genetics; human; liver cell carcinoma; liver tumor; metabolism

Citation Information

Scopus Citations: 10

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