Study of urinary n-acetyl-beta-d-glucosaminidase as a biomarker of diabetic nephropathy

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Mahmoud A.A.; Mostafa N.M.; Mesbah O.; Sabry O.M.; Al-Barshomy S.M.

Journal: Egyptian Journal of Hospital Medicine

Publisher: Ain Shams University Faculty of Medicine

Publication Date: 1 January 2021

Volume / Issue: Volume 82 / Issue 2

Pages: 231–236

Article No.: 9

ISSN: 16872002

DOI: 10.21608/EJHM.2021.142879

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access

Authors and Affiliations

Mahmoud A.A., Departments of Internal Medicine & Nephrology, Faculty of Medicine, Zagazig University, Egypt; Mostafa N.M., Nephrology, Faculty of Medicine, Zagazig University, Egypt; Mesbah O., Nephrology, Faculty of Medicine, Zagazig University, Egypt; Sabry O.M., Hematology, Theodor Bilharz Research Institute, Egypt; Al-Barshomy S.M., Departments of Internal Medicine & Nephrology, Faculty of Medicine, Zagazig University, Egypt

Abstract

Background: Diabetic nephropathy (DN) is a major cause of morbidity and mortality in diabetic patients worldwide. Plenty of tubular damage biomarkers have been discovered. Urinary N-acetyl-β-D-glucosaminidase (NAG) is a hydrolytic enzyme that acts on glycosyl compounds. NAG is excreted in abnormally high amounts in many renal diseases. Objective: The aim of this work was to study the importance of Urinary N acetyl-β-D-glucosaminidase level as an early biomarker for detection of DN and to assess the degree of kidney affection in various stages of DN. Patients and methods: 100 subjects divided into five groups: Group 1: 20 healthy volunteers (control group), group 2: 20 pre diabetic persons, group 3: 20 normo-albuminuria diabetic patients, group 4: 20 micro-albuminuria diabetic patients (ACR 3-300 mg/mmol) and group 5: 20 macro-albuminuria diabetic patients (ACR ≥ 300 mg/mmol). All individuals were subjected to full history taking, ECG & echocardiography, abdominal ultrasound, laboratory investigations (HbA1c, fasting and post prandial blood glucose, lipid profile, oral glucose tolerance test (OGTT), blood urea, serum creatinine, serum uric acid, e-GFR and urinary NAG. Results: There was high significant difference between the five groups regarding duration of the disease, fasting blood sugar, postprandial blood glucose, HbA1c, Serum cholesterol, albumin/creatinine ratio, serum urea and creatinine, e-GFR and urinary NAG. In addition, there was significant positive correlation between urinary NAG and albumin/creatinine ratio, blood urea, creatinine, and e-GFR. Conclusion: The urinary NAG can be used as an early urinary biomarker for early detection and progression of diabetic nephropathy in type 2 diabetic patients. © 2021, Ain Shams University Faculty of Medicine. All rights reserved.

Keywords

Diabetes; Nephropathy; Urinary N-Acetyl-Beta-D-glucosaminidase

Citation Information

Scopus Citations: 3

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