Pulmonary function test abnormalities in children and adolescents with non-alcoholic fatty liver disease

Theodor Bilharz Research Institute

Bibliographic Information

Authors: El Amrousy D.; El Ashry H.; Maher S.; Ganna S.; Hasan S.

Journal: European Journal of Pediatrics

Publisher: Springer Science and Business Media Deutschland GmbH

Publication Date: 21 January 2021

Volume / Issue: Volume 180 / Issue 6

Pages: 1693–1699

ISSN: 3406199

DOI: 10.1007/s00431-021-03941-3

Scopus: View on Scopus

PubMed: 33479799

Document Type: Article

Authors and Affiliations

El Amrousy D., Pediatric Department, Faculty of Medicine, Tanta University, El motasem street No 6, Tanta, Egypt; El Ashry H., Tropical Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt; Maher S., Theodor Bilharz Research Institute, Cairo, Egypt; Ganna S., Chest Diseases Department, Faculty of Medicine, Tanta University, Tanta, Egypt; Hasan S., Pediatric Department, Faculty of Medicine, Tanta University, El motasem street No 6, Tanta, Egypt

Abstract

Association between pulmonary function tests (PFTs) and non-alcoholic fatty liver disease (NAFLD) has been reported in adult studies; however, there is lack of pediatric studies. Our study aimed to evaluate PFTs in children with NAFLD. A total of 137 children with NAFLD and 100 healthy children of matched age and sex were included in the study. Different PFTs including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, residual volume (RV), and total lung capacity (TLC) were performed for all included children. Lipid profile, insulin resistance, fasting and postprandial glucose level, and high sensitive C reactive protein (hs-CRP) were measured. FEV1 %, FVC %, FEV1/FVC ratio, RV, and TLC were significantly lower in the patient group compared with the control group (P < 0.05), while RV and hs-CRP were significantly higher in children with NAFLD. Restrictive lung dysfunction was the commonest pulmonary dysfunction detected in children with NAFLD (21.9%). PFT indices were significantly correlated with grade and duration of NAFLD, insulin resistance, waist circumference, and hs-CRP. Regression analysis revealed that insulin resistance and hs-CRP were independently associated with decreased PFT indices. Conclusion: PFT indices were impaired in children with NAFLD and this impairment was independently associated with insulin resistance and hs-CRP.What is Known:• Pulmonary function tests (PFTs) abnormalities are common in adults with nonalcoholic fatty liver disease (NAFLD).• Studies involving PFTs abnormalities in pediatric NAFLD are lacking.What is New:• It is the first study that assessed PFT in pediatric patients with NAFLD.• PFTs abnormalities are present in children with NAFLD.• Insulin resistance and high sensitive C reactive protein are independently associated with the decline of PFTs in children with NAFLD. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.

Keywords

Adolescents; Children; hs-CRP; Insulin resistance; Non-alcoholic fatty liver disease; Pulmonary function; Adolescent; Adult; Child; Forced Expiratory Volume; Humans; Respiratory Function Tests; Vital Capacity; C reactive protein; glucose; high sensitive C reactive protein; unclassified drug; Article; controlled study; cross-sectional study; data analysis software; disease duration; echography; fasting; female; forced vital capacity; glucose blood level; hepatography; human; lipid fingerprinting; lung disease; lung function test; major clinical study; male; nonalcoholic fatty liver; priority journal; prospective study; residual volume; total lung capacity; waist circumference; complication

Citation Information

Scopus Citations: 6

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