Profiling inflammatory cytokines in a cohort study of Egyptian patients with COVID-19 infection

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Gharib A.F.; El Askary A.; Hassan A.F.; Ismail K.A.; Hagag H.M.; Khalifa A.M.; Sami R.; Amin H.S.; Youssef I.H.

Journal: Clinical Laboratory

Publisher: Verlag Klinisches Labor GmbH

Publication Date: 2021

Volume / Issue: Volume 67 / Issue 6

Pages: 1492–1500

ISSN: 14336510

DOI: 10.7754/Clin.Lab.2021.210420

Scopus: View on Scopus

PubMed: 34107645

Document Type: Article

Authors and Affiliations

Gharib A.F., Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia; El Askary A., Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia; Hassan A.F., Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia; Ismail K.A., Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia; Hagag H.M., Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia; Khalifa A.M., Forensic and Toxicology Department, Faculty of Medicine, Ain Shams University, Egypt; Sami R., Department of Food Science and Nutrition, College of Sciences, Taif University, Taif, Saudi Arabia; Amin H.S., Department of Clinical Chemistry, Theodor Bilharz Research Institute, Cairo, Egypt; Youssef I.H., Chest Department, Faculty of Medicine, Al Azhar University, Egypt

Abstract

Background: Coronavirus disease 2019 (COVID-19) pandemic is an international public health emergency with major disruptions and devastating health consequences resulting from the associated cytokine storm syndrome. The aim of our research was to assess the inflammatory biomarkers and risk factors associated with severity of (COVID-19) patients. Methods: A cross-sectional study was conducted and included 150 Egyptian patients with COVID-19. Patients were classified into mild, moderate, and severe according to the clinical and CT chest findings. Blood samples were collected from patients for laboratory assessment of inflammatory biomarkers. Results: Our results showed significant negative correlation between oxygen saturation percent and serum levels of inflammatory markers. The correlations were statistically significant with IL-6, CRP, ferritin, LDH, and D-di-mer which can be used as sensitive biomarkers for assessment of the risk of severity of infection in COVID 19 pa-tients. Conclusions: The study revealed that the risk factors associated with severity of COVID 19 infection included older age, male gender, presence of underlying chronic disease, and increased levels of inflammatory biomarkers: CRP, LDH, ferritin, IL-6, and D-dimer. © 2021 Verlag Klinisches Labor GmbH. All rights reserved.

Keywords

COVID-19; Egyptian patients; Inflammatory biomarkers; Aged; Biomarkers; Cohort Studies; Cross-Sectional Studies; Cytokines; Egypt; Humans; Male; SARS-CoV-2; Severity of Illness Index; biological marker; C reactive protein; cytokine; D dimer; ferritin; gamma interferon; interleukin 6; lactate dehydrogenase; tumor necrosis factor; adult; Article; blood level; blood sampling; chronic disease; chronic obstructive lung disease; cohort analysis; comorbidity; controlled study; coronary artery disease; coronavirus disease 2019; correlation analysis; cross-sectional study; diabetes mellitus; Egyptian; female; human; hypertension; major clinical study; obesity; oxygen saturation; risk factor

Citation Information

Scopus Citations: 2

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