Effects of free and nanoparticulate curcumin on chemically induced liver carcinoma in an animal model

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Mohammed E.S.; El-Beih N.M.; El-Hussieny E.A.; EL-Ahwany E.; Hassan M.; Zoheiry M.

Journal: Archives of Medical Science

Publisher: Termedia Publishing House Ltd.

Publication Date: 2021

Volume / Issue: Volume 17 / Issue 1

Pages: 218–227

ISSN: 17341922

DOI: 10.5114/aoms.2020.93739

Scopus: View on Scopus

Document Type: Article

Access: All Open Access; Gold Open Access; Green Open Access

Authors and Affiliations

Mohammed E.S., Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt; El-Beih N.M., Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt; El-Hussieny E.A., Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt; EL-Ahwany E., Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt; Hassan M., Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt; Zoheiry M., Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

Introduction: Curcumin therapeutic applications are constrained by its prominent metabolic instability as well as inadequate absorption and bioavailability. The current study was designed to enhance the curcumin bioavailability by exploiting nanoparticles. Material and methods: Eleven groups of mice were divided into: normal and nanoparticle control groups, a hepatocellular carcinoma (HCC) group induced by diethylnitrosamine (DEN), 2 groups treated with DEN plus a high dose/low dose of free curcumin, 2 groups treated with a high dose/low dose of free curcumin, 2 groups treated with DEN plus a high dose/low dose of nanoparticulate curcumin, and 2 groups treated with a high dose/low dose of nanoparticulate curcumin. Results: DEN administration significantly increased liver enzymes, vascular endothelial growth factor, tumor necrosis factor-α, α-fetoprotein, malondialdehyde, and nucelar factor-kB. Also, it decreased serum albumin and tissue antioxidant activities and caused severe histological changes in hepatic tissue. Oral treatment of DEN-injected mice with either a high dose of free curcumin or the tested doses of nanoparticulate curcumin resulted in a significant improvement of all the tested parameters. Conclusions: Although the two tested doses of nanoparticulate curcumin were much lower than free curcumin, both doses were effective in preventing HCC development while the low dose of free curcumin was hardly effective. Hence, we conclude that nanoparticles enhance the bioavailability of curcumin. © 2020 Termedia & Banach.

Keywords

Curcumin; Diethylnitrosamine (DEN); Hepatocellular carcinoma; Nanoparticles; alanine aminotransferase; alkaline phosphatase; alpha fetoprotein antibody; antineoplastic agent; caspase 3; catalase; diethylnitrosamine; immunoglobulin enhancer binding protein; malonaldehyde; nanoparticle; nanoparticulate curcumin; serum albumin; silver nanoparticle; tumor necrosis factor; unclassified drug; vasculotropin; alanine aminotransferase blood level; alkaline phosphatase blood level; animal experiment; animal model; animal tissue; antioxidant activity; Article; cancer combination chemotherapy; controlled study; drug bioavailability; drug effect; drug megadose; histopathology; liver cell carcinoma; liver tissue; low drug dose; male; mouse; nonhuman; protein blood level

Citation Information

Scopus Citations: 72

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