Ascitic Fluid Cytokines in Chronic Liver Disease: A Possible Prognostic Tool

Theodor Bilharz Research Institute

Bibliographic Information

Authors: Atta S.; Kamel M.; Mansour W.; Hussein T.; Maher K.; Elrefaiy M.A.

Journal: Digestive Diseases

Publisher: S. Karger AG

Publication Date: 13 January 2021

Volume / Issue: Volume 39 / Issue 5

Pages: 534–539

ISSN: 2572753

DOI: 10.1159/000514356

Scopus: View on Scopus

PubMed: 33440370

Document Type: Article

Authors and Affiliations

Atta S., Department of Immunology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Kamel M., Department of Immunology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Mansour W., Department of Immunology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Hussein T., Physiology Departement, Egyptian Drug Organization, Giza, Egypt; Maher K., Department of Immunology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt; Elrefaiy M.A., Department of Hepatogastroenterology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt

Abstract

Introduction: Malignant ascites results from imbalance between protein in the peritoneal cavity and absorption of fluids via the lymphatic system. More than 20 interleukins (ILs) are known to play an important role in the protection against tumors. Materials and Methods: Ascitic fluid IL-1B, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γlevels were assessed in 45 patients with liver cirrhosis and ascites as judged by histopathological and ultrasonographic findings. They were divided into 2 groups according to presence of hepatic focal lesions. Ten patients with focal hepatic lesions were randomly selected and subjected to analysis of serum levels of IL-2 and IL-10. Results: Ascitic fluid IL-4, IL-6 and IL-10 levels were found to be significantly higher in patients with hepatocellular carcinoma (HCC) than patients with cirrhosis. TNF-α, and IFN-γwere also found to be higher in HCC than patients with cirrhosis but with no significance. On the other hand, there was no significant difference in levels of IL-1B and IL-2 between the 2 groups. Ascitic fluid IL-2 and IL-10 levels were found to be higher in ascitic fluid than in serum of the same patients. Conclusion: Ascitic fluid levels of IL-4, IL-6 and IL-10 are higher in HCC patients than patients with cirrhosis alone. Levels of ascitic fluid IL-2 and IL-10 proved to be a better prognostic tool than their levels in sera of the same patients. To conclude, patients with cirrhosis may be subjected to scheduled examination of ascitic fluid cytokines to predict transformation into HCC. © 2021

Keywords

Ascitic fluid; Cytokines; Hepatocellular carcinoma; Ascites; Carcinoma, Hepatocellular; Humans; Liver Cirrhosis; Liver Neoplasms; Prognosis; alanine aminotransferase; alpha fetoprotein; aspartate aminotransferase; cytokine; gamma interferon; interleukin 10; interleukin 1beta; interleukin 2; interleukin 4; interleukin 6; T lymphocyte receptor; tumor necrosis factor; adult; aged; Article; ascites fluid; cancer patient; cancer prognosis; chronic liver disease; clinical article; colonoscopy; echography; female; gene expression; histopathology; human; jaundice; liver cell carcinoma; male; myofibroblast; natural killer cell; peritoneal cavity; portal vein thrombosis; protein blood level; protein expression; randomized controlled trial; sigmoidoscopy; complication; liver tumor

Citation Information

Scopus Citations: 7

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