Recent advances in medicinal secondary metabolites from marine Streptomyces
Bibliographic Information
Authors: Hamed A.A.; El Awady M.E.; Selim M.S.; Selim H.M.R.M.; Mohamed S.S.; Ghareeb M.A.
Journal: Marine Microbiome and Microbial Bioprospecting: Diversity and Bioactive Potential
Publisher: Elsevier
Publication Date: 2026
Pages: 249–271
DOI: 10.1016/B978-0-443-26771-0.00017-5
Scopus: View on Scopus
Document Type: Book chapter
Authors and Affiliations
Hamed A.A., Microbial Chemistry Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt; El Awady M.E., Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt; Selim M.S., Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt; Selim H.M.R.M., Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia; Mohamed S.S., Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt; Ghareeb M.A., Medicinal Chemistry Department, Theodor Bilharz Research, Institute, Giza, Kornaish El Nile, Egypt
Abstract
The marine environment encompasses a significant portion of the world's biosphere, serving as a fundamental source of bioactive compounds for human investigation. Unique environments such as high salt concentrations, low temperatures, high pressures, low nutrient levels, and the absence of light have resulted in the distinctive production of bioactive substances compared to terrestrial sources. Naturally occurring ingredients extracted from marine-derived Streptomyces bacteria yield pharmaceutically active compounds. Various evidences suggest that bioactive compounds isolated from marine organisms may offer alternative avenues for discovering novel medicines, including antibiotics, antitumor agents, antiinflammatory drugs, and antiviral agents. This review focuses on naturally occurring metabolites from marine Streptomyces species, which possess distinct chemical structures that could aid in synthesizing recent medicines to combat resistant human pathogens. Advancements in science and technology facilitate the discovery of bioactive compounds derived from the marine environment. © 2026 Elsevier Inc. All rights reserved.
Keywords
Bioactivities; Drug discovery; MNPs; Secondary metabolites; Streptomycetes; Antibiotics; Bacteria; Bioactivity; Biomolecules; Biotic; Marine biology; Medicinal chemistry; Medicine; Metabolites; Bioactive compounds; High salt concentration; Lows-temperatures; Marine environment; Marine streptomyces; MNP; Naturally occurring; Antiviral agents
Citation Information
Scopus Citations: 0
For comprehensive information about the Theodor Bilharz Research Institute (TBRI), its institutional activities, scientific and research achievements, clinical and hospital services, and the diverse expertise offered through its 22 specialized research and clinical departments, as well as opportunities for professional training, specialized workshops, and scientific conferences, readers are invited to visit the Institute’s official website.
The website provides regularly updated information on the Institute’s latest news, research activities, scientific initiatives, clinical services, institutional programs, and academic and professional opportunities.
English Website: https://www.tbri.sci.eg/en/
Arabic Website: https://www.tbri.sci.eg/ar/
Prepared and Uploaded by:
Abdalla F. Abdalla
Electronic Portal Unit
